Cysteamine

Phosphate Ester

(CPE)

Better Absorption, Faster Growth

Rethinking Traditional Cysteamine Products

Cysteamine promotes growth mainly by depleting somatostatin (SS).

Traditional cysteamine hydrochloride products use fatty acid coatings to improve taste & stability, but face key problems:

· Incomplete coating → strong gastrointestinal irritation, ulcers, and reduced appetite.

· Slow or mislocated release → low absorption and poor bioavailability.

· Easily oxidized → loss of active ingredients and bad odor.

· Poor disintegration in poultry and aquaculture → even lower utilization.

Univet employs an acid-catalyzed esterification reaction combined with mucosal permeation technology —

Cysteamine Phosphate Ester (CPE)

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· Stabilizes the active compound, and reduces irritation and odor caused by free cysteamine.

· Inhibits oxidation; advances absorption Tmax to 0.75 h, improving gastrointestinal uptake.

· Balances pH, alleviates irritation, buffers acid–base reactions; elevates Cmax to >3 μg/mL, improving palatability.

· Converts cysteamine from its free hydrochloride form into a phosphate derivative, avoiding strong irritation and ulcer risks of cysteamine hydrochloride.

· Surface-active technology enhances mucosal permeability, significantly increasing cysteamine epithelial absorption efficiency: absorption peak ↑61.4%, AUC ↑70.5%.

Cysteamine Phosphate Ester (CPE) vs. Coated Cysteamine: Significantly Enhanced Absorption Efficiency

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Cysteamine Phosphate Ester (CPE) vs. Guanidinoacetic Acid

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Usage

Swine: 100–200 g/T of complete feed. Supports digestion and growth, reduces fat deposition, improves body conformation.

Poultry: 50–100 g/T of complete feed. Promotes growth, reduces stress, enhances carcass quality.

Ruminants: 100–200 g/T of concentrate supplement. Increases feed intake and growth, improves coat quality, significantly enhances body conformation, and increases milk yield during lactation.